Beta-substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine beta-hydroxylase

J Med Chem. 1988 Apr;31(4):704-6. doi: 10.1021/jm00399a002.

Authors

L I Kruse¹, C Kaiser, W E DeWolf Jr, P A Chambers, P J Goodhart, M Ezekiel, E H Ohlstein

Affiliation

¹ Department of Medicinal Chemistry, Smith Kline & French Laboratories, Swedeland, Pennsylvania 19406.

PMID: 3351845
DOI: 10.1021/jm00399a002

No abstract available

MeSH terms

Animals
Blood Pressure / drug effects
Cattle
Dopamine beta-Hydroxylase / antagonists & inhibitors*
Hypertension / enzymology
Kinetics
Phenethylamines / pharmacology*
Rats
Rats, Inbred SHR
Structure-Activity Relationship
Time Factors

Substances

Phenethylamines
Dopamine beta-Hydroxylase